I was on depo for years without any problems. I did gain about 20 lbs. but I also became a SAHM the same time I started depo. When I started working again I dropped all the weight in 3 months. Now I have an IUD but am ready for something a bit more permanent. Once the adoption of our little girl goes through DH or I (or both) will get fixed. I am happy with our 3 kids and do not feel the need to have any more.